Ayrtal
July 22, 2010 – 10:00 pmName: Ayrtal
Prescription name: Ayrtal
International name: Atseklofenak (Aceclofenac)
Group affiliation: NSAIDs
Description of existing substances (INN): Atseklofenak
Dosage form: coated tablets
Pharmacological action: NSAIDs, a derivative of phenylacetic acid has anti-inflammatory, analgesic and antipyretic effect associated with the indiscriminate suppression TSOG1 and TSOG2 regulating the synthesis of Pg.
Indications: Inflammatory diseases of musculoskeletal system (rheumatoid arthritis, psoriatic, and juvenile arthritis, ankylosing spondylitis; gouty arthritis, osteoarthritis).
Contraindications: Hypersensitivity (including to other NSAIDs), erosive and ulcerative lesions GIT (exacerbation), “Aspirin triad” (a combination of asthma, recurrent nasal polyposis, and paranasal sinuses and intolerances ASA and LS pirazolonovogo series) hemodyscrasia unknown etiology, pregnancy (III trimester), children’s age (18 years). C carefully. CHF, liver disease, kidney and gastrointestinal history, dyspeptic symptoms at the time the medication, hypertension, lower BCC (including state after surgical intervention), pregnancy (I-II trimester), lactation, old age, chronic renal failure , diuretics.
Side effects: the part of the digestive system: stomachalgia, nausea, vomiting, dyspepsia, flatulence, loss of appetite , increased activity of “liver” enzymes, gastrointestinal bleeding, erosive and ulcerative lesions and perforation of the gastrointestinal tract, gematemezis, melena, fulminant hepatitis, and constipation. Of the nervous system: headache, dizziness, agitation, disruption of perception, paresthesia, memory decline, disorientation, blurred vision, hearing, taste, tinnitus, sleep disturbances (drowsiness or insomnia), irritability, convulsions, depression, anxiety, tremor, aseptic meningitis. Allergic reactions: skin rash, rarely – hives, eczema, erythroderma, systemic anaphylactoid reactions, asthma, and in some cases – vasculitis, pneumonitis, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome ). From the urinary system: rarely – peripheral edema, in some cases – acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome. From the side of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia, aplastic anemia. From the CCC: tachycardia, increased blood pressure, chronic heart failure. Overdose. Symptoms: dizziness, headache, hyperventilation lungs with increased convulsive readiness, nausea, vomiting, abdominal pain. Treatment: gastric lavage, the introduction of activated charcoal, symptomatic therapy. No specific antidote. Forced diuresis, hemodialysis ineffective.
Dosage and administration: Inside, 100 mg 2 times a day. Swallow whole tablets, drinking plenty of fluids.
Special instructions: Because of the important role of Pg in the maintenance of renal blood flow should be particularly careful when patients have with cardiac or renal failure, advanced age, taking diuretics, and patients who for whatever reason, the decrease of the bcc (eg after a major surgical intervention). While in such cases, appoint atseklofenak, recommend as a precautionary measure to monitor renal function. Patients with hepatic insufficiency (chronic hepatitis, compensated cirrhosis) kinetics and metabolism did not differ from similar processes in patients with normal liver function. When conducting long-term therapy necessary to control the function of the liver, peripheral blood picture, analysis of fecal occult blood. During the period of treatment must be careful when driving and other lesson potentially dangerous activities which require high concentration and speed of psychomotor reactions.
Interaction: Increases in plasma concentration of digoxin, drugs Li + and phenytoin. Against the background of the simultaneous reception of potassium-sparing diuretics increase the risk of hyperkalemia on the background of indirect anticoagulants – the risk of bleeding (requires regular monitoring of blood clotting). It reduces the effectiveness of diuretic and antihypertensive drugs. It increases the likelihood of side effects of NSAIDs and the MCS from the gastrointestinal tract, the toxicity of methotrexate (the interval between doses – 24 h) and cyclosporine nephrotoxicity. ASA reduces the concentration of atseklofenaka in the blood. When applied simultaneously with oral hypoglycemic drugs may be both hypo-and hyperglycemia (requires monitoring blood glucose). Myelotoxic drugs increase the expression gematotoksichnosti drug.
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